Lallbiome™ 200

We supply Active ingredients for the development of personal care products.

Our topical active ingredients, made exclusively from microorganisms, fractions, or microorganism-derived products, are formulated specifically for personal care.

For the cosmetics industry, these microorganisms are creating new opportunities to innovate, especially in the emerging field of microbiome skin care.

Lallbiome™ 200: Innovative Postbiotics for Personal Care

Senescence is the process where cells lose their ability to divide and function, leading to the accumulation of damaged cells that contribute to aging. In the skin, this results in visible signs of aging such as wrinkles, loss of elasticity, and uneven pigmentation.

The role of senescent Cells (“Zombie” Cells, or “Z-cells”) in aging

Senescent cells, often referred to as ‘zombie’ cells, are cells that have stopped dividing but don’t undergo apoptosis. These cells accumulate with age and secrete harmful chemicals that damage nearby healthy cells, contributing to aging and various health issues.

Zombie cells arise from different types of cellular damage or stress, such as DNA damage from UV radiation or oxidative stress. These senescent cells secrete inflammatory factors to alert the immune system. Ideally, natural killer cells would remove them through autophagy. However, when these cells persist, they cause chronic inflammation and stem cell exhaustion, accelerating aging and contributing to age-related diseases.

Lallbiome™ 200, supporting Healthy Aging

Lallemand uses its expertise in microorganisms to develop inactivated bacteria, known as postbiotics, for the cosmetic market. Lallbiome™ 200 is an inactivated Lactobacillus Helveticus, a bacterium that is no longer alive but still biologically active.

Lactobacillus Helveticus HA122, a heat-inactivated postbiotic, helps manage the effects of zombie cells. It reduces harmful inflammatory signals and supports overall immune function, creating a more favorable environment for the immune system to clear senescent cells, thereby mitigating their impact on neighboring cells.

These Gram-positive bacteria have a thick outer layer called peptidoglycans (PGN), which communicate with the skin to generate beneficial responses. The bacteria are inactivated through a gentle heat treatment that stops their reproduction but keeps their structure intact.